Funded
Research

Arla Food for Health has initiated 14 research projects during the first five years of its existence.

Arla Food for Health (AFH) is based on the conviction that equal collaboration through independent research activities, both nationally and internationally, are crucial for the ability to address several global health challenges.

The ambition is to push boundaries and foster world-class dairy science. Subsequently results can be applied in food design and new nutritional solutions with positive impact on global nutritional sta-tus and public health – this will create value for individuals, the society and the collaborating part-ners.

The AFH partners are committed to create impact and objectively disseminate the scientific insights developed through the AFH-projects. The collaboration between the partners include a targeted and coordinated public outreach that can serve as basis for a science based nutrition and health dia-logue with external stakeholders – including authorities, NGO’s, universities and other industries.

The funded research projects:

All projects have participation from University of Copenhagen, Aarhus University, Arla Foods Ingredients Group P/S and Arla Foods amba. Below you’ll find a brief description of these 14 projects.

DAIPRO-NAFLD – A randomized controlled trial of effects of DAIry PROtein products on liver disease severity and metabolism in patients with Non-Alcoholic Fatty Liver Disease.

The project will investigate the effects of novel dairy protein products on liver disease severity and metabolism in patients with non-alcoholic fatty liver disease (NAFLD). This may procure novel treatments and dietary guidelines for patients with NAFLD and holds potential for extrapolation to obesity and diabetes.

Principal Investigator

Professor Henning Grønbæk, Aarhus University.

The CutDM mealbox – Cut down on carbohydrate usage in the diet of type 2 diabetes

The project objective is to examine whether 12 months of provision of a carbohydrate-reduced high-protein (CRHP) diet as compared to dietary counseling to follow a CRHP diet or provision of a conventional diabetes (CD) diet can reduce medication and improve blood glucose control and key risk factors for metabolic and cardiovascular disease in patients with T2D.

Principal Investigator

Professor Thure Krarup, University of Copenhagen.

FerMetS – Matrix characterization and effect of different types fermented dairy products on liver fat, cardiometabolic risk and gut microbiome in men with metabolic syndrome.

The project aim to characterize the matrix of different types of fermented dairy products and investigate their effects on liver fat, cardio metabolic risk and gut microbiome when compared with a dairy-control in men with metabolic syndrome

Principal Investigator

Professor Arne Astrup, University of Copenhagen

ENMET – Milk proteins as regulator of obesity through modification of the ENergy METabolism and gut microbiota

This project investigates to what extent milk proteins modulate energy metabolism and thereby may improve weight management. The project aims in addition to investigate the molecular mechanisms governing the effect of protein on host metabolism in consort with gut bacteria.

Principal Investigator

Professor Karsten Kristiansen, University of Copenhagen

AFH funded

3.5 mill. DKK

OmniSaM: The Omnibus Satiety Metric

A multimodal metric for predicting the satiating effects of real foods and drinks

Satiation depends on many human factors related to e.g. physiology, perception and psychology and as such has proven very difficult to measure and predict accurately. Healthy foods that fill faster and for longer are desirable for public health, but current methods for measuring the satiating capacity of foods have very weak predictive val-ues. This ambitious project proposes to combine the primary processes underlying the satiety cascade, including brain, blood and behavior measurements to develop a meth-od which can accurately predict future caloric intake. The Omnibus Satiety Metric will enable the development of superior satiety optimized foods in the context of weight and lifestyle management for the consumer, as well as enabling the future development of a rapid measurement for satiation with wider applicability in the nutrition and medical sectors.

Publications
Which factors decide how much we eat? DCA –Center for Food and Agriculture. April 2019. Popular science.

Principal Investigator

Professor and Science Team Leader Derek Victor Byrne, Food Quality Perception and Society, Department of Food Science, Aarhus University

AFH funded

5.29 mill DKK

Take

When sick and hospitalized muscle wasting often take place due to inflammation and lack of appetite. This project investigates the optimal combination of milk proteins and ketone bodies to counteract post-inflammatory protein and muscle waste in a new clinical human model combining inflammation(LPS), bed rest and fasting. The goal is to be able to support healing and recovery with targeted nutrition, which would improve quality of life for patients and reduce health care costs.

Principal Investigator

Professor Niels Møller, Aarhus University Hospital

AFH funded

1.65 mill DKK

DAIRYMAT

A food item is more than the content of its single nutrients. The structure of the food at all levels affects the digestion and uptake of the nutrients in the human gut. In this project, we study how the dairy matrix influences nutrient uptake with specific focus on post-prandial lipaemia. The perspective is to be able to design better foods with a more targeted structure for nutrient availability by understanding of the effects of this relationship in dairy foods.

Principal Investigator

Marianne Hammershøj, Aarhus University

AFH funded

4 mill DKK

MAGMAM

At any time at least 50 mill. children suffer from malnutrition, which has huge consequences for their future life – if they survive. Optimal nutrition support is needed to bring children out of this devastating state of hunger and impaired growth and development. This project examines how milk protein and whey permeate rescue linear and ponderal growth as well as child development in Moderate Acute Malnutrition.

Principal Investigator

Professor Henrik Friis, University of Copenhagen

AFH funded

5 mill DKK

MiPUAge – Milk Protein Utilisation and Age

Whey and casein-derived protein ingredients: gastro-intestinal absorbption, whole body utilizatoin, and hormonal and metabolic regulation: a metabolomics approach.

Principal Investigator

Professor, Gerrit van Hall, University of Copenhagen

AFH funded

3.65 mill DKK

D-pro

Effects of milk protein and vitamin D on children’s growth and health.

Principal Investigator

Professor, Christian Mølgård, University of Copenhagen

AFH funded

6.35 mill DKK

MAINHEALTH

The influence of maternal health on human breast milk composition with downstream effects on infant metabolism and gut colonization.

Principal Investigator

Ulrik Kræmer Sundekilde, Aarhus University
Niels Uldbjerg, Aarhus University
Dennis Sandris Nielsen, University of Copenhagen

AFH funded

5.0 mill DKK

Finalized research projects

InfantBrain

A large project in which work package 1 is funded by Arla Food for Health. This work package aims to identify and optimize processing conditions which allow efficient and high quality separation of Milk Fat Globule Membrane (MFGM) from cream or dairy side streams.

Publications
Placing pasteurisation before or after microfiltration impacts the protein composition of milk fat globule membrane material

Microfiltration of raw milk for production of high-purity milk fat globule membrane material

Impact of industrial cream heat treatments on the protein composition of the milk fat globule membrane

Principal Investigator

Assoc. Professor Lars Wiking, Aarhus University

AFH funded

2.5 mill DKK

CutDM – Cut down on carbohydrate usage in the diet of type 2 diabetes

Mechanisms of effective therapy of diabetes by selective choice of macronutrients

This project investigates if a diet with lower content of carbohydrates and thus higher content of fat and protein, partly delivered by dairy products, improves blood sugar control of patients suffering from Type 2 Diabetes.

Publication

A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomize controlled trial​

Principal Investigator

Chief Phycisian, DMsc Thure Krarup, University of Copenhagen

AFH funded

4.0 mill DKK

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